Bioinformatics Analysis pipeline of Whole-Genome Sequence Data to Investigate Antimicrobial Resistance

Methy-Pipe: An Integrated Bioinformatics Pipeline for Whole Genome Bisulfite Sequencing Data Analysis

DNA methylation, one of the most important epigenetic modifications, plays a crucial role in various biological processes. The level of DNA methylation can be measured using whole-genome bisulfite sequencing at single base resolution. However, until now, there is a paucity of publicly available software for carrying out integrated methylation data analysis. In this study, we implemented Methy-P...

Whole-genome sequencing to control antimicrobial resistance

Following recent improvements in sequencing technologies, whole-genome sequencing (WGS) is positioned to become an essential tool in the control of antibiotic resistance, a major threat in modern healthcare. WGS has already found numerous applications in this area, ranging from the development of novel antibiotics and diagnostic tests through to antibiotic stewardship of currently available dru...

Acquired Antimicrobial Resistance Genes of Escherichia coli Obtained from Nigeria: In silico Genome Analysis

Background: Antimicrobial resistance is a global problem with enormous public health and economic impact. This study was carried out to get an overview of acquired antimicrobial resistance gene sequences in the genomes of Escherichia coli isolated from different food sources and the environment in Nigeria. Methods: To determine the acquired antimicrobial-resistant genes prevalence, genome asse...

Whole Genome Sequencing Introduction to the Interpretation of Whole Genome Sequence Data in Food Safety

I ntroduction Whole genome sequencing (WGS) for bacterial foodborne pathogen characterization is here to stay. Developments in WGS platforms have made it possible to sequence the entire genome of bacteria at prices comparable to common molecular subtyping methods. These data can provide nearperfect discrimination of bacterial isolates. While common molecular subtyping methods only interrogate s...

Bioinformatics and Whole Genome Technologies